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solute carrier family 2 member 4; glucose transporter type 4, insulin-responsive; GLUT-4 (SLC2A4, GLUT4)
Function:
- insulin-regulated facilitative glucose transporter
- insulin recruits GLUT4 to the plasma membrane
- binds to DAXX
- interacts via its N-terminus with SRFBP1
- sumoylated
Structure:
- belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily
Compartment:
- intracytoplasmic membrane, perinuclear region
- localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized
- the dileucine internalization motif is critical for intracellular sequestration
- insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (putative)
Expression:
- expressed in skeletal & cardiac muscles; brown & white fat
Pathology:
- defects in SLC2A4 may be a cause of diabetes mellitus type 2 non-insulin dependent (NIDDM)
- defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM
- the variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects
General
glucose transporter
solute carrier family 2 (SLC2, SLC2A)
Properties
SIZE: entity length = 509 aa
MW = 55 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: cytoplasmic domain {1-24}
MOTIF: binding site
SITE: 7-13
FOR-BINDING-OF: serum response factor-binding protein 1
transmembrane domain {25-45}
exoplasmic loop {46-81}
MOTIF: N-glycosylation site {N57}
transmembrane domain {82-102}
cytoplasmic loop {103-111}
transmembrane domain {112-132}
exoplasmic loop {133-142}
transmembrane domain {143-163}
cytoplasmic loop {164-171}
transmembrane domain {172-192}
exoplasmic loop {193-201}
transmembrane domain {202-222}
cytoplasmic loop {223-287}
transmembrane domain {288-308}
MOTIF: Defines substrate specificity {295-297}
exoplasmic loop {309-323}
transmembrane domain {324-344}
cytoplasmic loop {345-353}
transmembrane domain {354-374}
exoplasmic loop {375-384}
transmembrane domain {385-405}
cytoplasmic loop {406-417}
transmembrane domain {418-438}
exoplasmic loop {439-445}
transmembrane domain {446-466}
cytoplasmic domain {467-509}
MOTIF: Dileucine internalization {489-490}
MISC-INFO: KM 5 MM
Database Correlations
OMIM correlations
MORBIDMAP 138190
UniProt P14672
Pfam PF00083
Kegg hsa:6517
References
- UniProt :accession P14672
- Wikipedia; Note: GLUT4 entry
http://en.wikipedia.org/wiki/glut4
- Unger RH
Diabetic hyperglycemia: link to impaired glucose transport in
pancreatic beta cells.
Science 251:1200 1991
PMID: 2006409
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 744