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solute carrier family 2 member 1; glucose transporter type 1, erythrocyte/brain; GLUT-1; hepG2 glucose transporter (SLC2A1, GLUT1)
Function:
- facilitative glucose transporter
- may be responsible for constitutive or basal glucose uptake
- very broad substrate specificity; can transport a wide range of aldoses including both pentoses & hexoses
- phosphorylated upon DNA damage, probably by ATM or ATR
- facilitates glucose uptake at glucose concentrations below normal fasting range (3-6 mM)
Structure:
- belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily
Compartment:
- cell membrane
- melanosome
- localizes primarily at the cell surface (putative)
Expression:
- expressed at variable levels in many human tissues
- expressed in brain
Pathology:
- defects in SLC2A1 are the cause of autosomal dominant GLUT1 deficiency syndrome
Pharmacology:
- triheptanoin (Dojolvi) used experimentally to treat GLUT1 deficiency syndrome
General
glucose transporter
phosphoprotein
solute carrier family 2 (SLC2, SLC2A)
Properties
SIZE: MW = 45 kD
MW = 55 kD
COMPARTMENT: plasma membrane
CELL: erythrocyte
endothelial cell
WITHIN: blood-brain barrier
astrocyte
WITHIN: central nervous system
MOTIF: cytoplasmic domain {1-12}
transmembrane domain {13-33}
exoplasmic loop {34-66}
MOTIF: N-glycosylation site {N45}
transmembrane domain {67-87}
cytoplasmic loop {88-95}
transmembrane domain {96-116}
exoplasmic loop {117-126}
transmembrane domain {127-147}
cytoplasmic loop {148-155}
transmembrane domain {156-176}
exoplasmic loop {177-185}
transmembrane domain {186-206}
cytoplasmic loop {207-271}
transmembrane domain {272-292}
exoplasmic loop {293-307}
transmembrane domain {308-328}
cytoplasmic loop {329-337}
transmembrane domain {338-358}
exoplasmic loop {359-371}
transmembrane domain {372-392}
cytoplasmic loop {393-401}
transmembrane domain {402-422}
exoplasmic loop {423-429}
transmembrane domain {430-450}
cytoplasmic domain {451-492}
MISC-INFO: KM 1-2 MM
Database Correlations
OMIM correlations
MORBIDMAP 138140
UniProt P11166
Pfam PF00083
Kegg hsa:6513
References
- Unger RH
Diabetic hyperglycemia: link to impaired glucose transport in
pancreatic beta cells.
Science 251:1200 1991
PMID: 2006409
- Stryer Biochemistry WH Freeman & Co, New York,
1988 pg 536
- Maher F, Vannucci SJ, Simpson IA.
Glucose transporter proteins in brain.
FASEB J. 1994 Oct;8(13):1003-11. Review.
PMID: 7926364