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ceramide glucosyltransferase; GLCT-1; glucosylceramide synthase; GCS; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase (UGCG)
Function:
- catalyzes 1st glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide
- may also serve as a flippase
- lipid metabolism; sphingolipid metabolism
Structure: belongs to the glycosyltransferase 2 family
Compartment:
- endoplasmic reticulum membrane; multi-pass membrane protein
Expression: found in all tissues examined
General
glucosyl transferase
transmembrane 3 protein
Properties
SIZE: entity length = 394 aa
MW = 45 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-10}
transmembrane domain {11-31}
cytoplasmic loop {32-285}
MOTIF: histidine residue {193}
transmembrane domain {286-306}
exoplasmic loop {307-313}
transmembrane domain {314-334}
cytoplasmic loop {335-348}
transmembrane domain {349-369}
Database Correlations
OMIM 602874
UniProt Q16739
Pfam PF00535
Entrez Gene 7357
Kegg hsa:7357
References
- UniProt :accession Q16739
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/