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Na+/glucose cotransporter
Function:
- Na+ is co-tranported with glucose
- the Na+ gradient provides the driving force for the transport
- efficient substrate transport in mammalian kidney is provided by a low affinity high capacity & a high affinity low capacity Na+/glucose cotransporter arranged in series along kidney proximal tubules
Structure:
- binding sites for glucose & Na+
Specific
Na+/glucose cotransporter 1 (high affinity Na+-glucose cotransporter, solute carrier family 5 member1, SLC5A, NAGT, SGLT1)
Na+/glucose cotransporter 3 (low affinity Na+-glucose cotransporter, solute carrier family 5 member 4, SLC5A4, SAAT1, SGLT3)
Na+/glucose cotransporter 5 (Na+/glucose cotransporter 5, solute carrier family 5 member 10, SLC5A10, SGLT5)
General
glucose transporter
Properties
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {N-TERMINAL}
exoplasmic loop
LOOP#: 1
exoplasmic loop
MOTIF: N-glycosylation site
cysteine residue {L2.1}
MODIFICATION: cysteine residue {L2.2}
cysteine residue {L2.2}
MODIFICATION: cysteine residue {L2.1}
LOOP#: 2
exoplasmic loop
LOOP#: 3
exoplasmic loop
LOOP#: 4
exoplasmic loop
LOOP#: 5
exoplasmic loop
LOOP#: 6
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain {TM8}
transmembrane domain {TM9}
transmembrane domain {TM10}
transmembrane domain {TM11}
transmembrane domain {TM12}
cytoplasmic loop
LOOP#: 1
cytoplasmic loop
LOOP#: 2
cytoplasmic loop
LOOP#: 3
cytoplasmic loop
LOOP#: 4
cytoplasmic loop
LOOP#: 5
cytoplasmic domain {C-TERMINAL}
References
- Unger RH
Diabetic hyperglycemia: link to impaired glucose transport in
pancreatic beta cells.
Science 251:1200 1991
PMID: 2006409
- Textbook of Medical Physiology, 8th ed., AC Guyton,
WB Saunders, Philadelphia, 1991, pg 48
- UniProt :accession P13866