glucagon-like peptide 2 (GLP2)

Function: - derived from proglucagon - stimulates intestinal growth & up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation & decreased enterocyte apoptosis - the GI tract, from the stomach to the colon is the principal target for GLP-2 action. - role in nutrient homeostasis - enhances nutrient assimilation through enhanced GI function - increases nutrient clearance - stimulates intestinal glucose transport - decreases mucosal permeability Pharmacokinetics: - 1/2life is 1-2 minutes Expression: - GLP-1, GLP-2, oxyntomodulin & glicentin are secreted from enteroendocrine cells throughout the GI tract - GLP-1 & GLP-2 are also secreted in selected neurons in the brain - GLP-1 & GLP-2 are induced in response to nutrient ingestion Comparative biology: - found in mammals only

General

endocrine agent incretin secretin family peptide

Properties

COMPARTMENT: extracellular compartment

Database Correlations

OMIM 138030 UniProt P01275

References

prosite :accession PS00260