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glomangioma; glomus tumor; glomuvenous malformation

A tumor of the glomus body. Pathology: - smooth-muscle-like glomus cells in the tunica media surrounding distended vascular lumens Genetics: -> mutations in glomulin gene Clinical manifestations: 1) exquisitely tender subungual papule or nodule 2) paroxysmal painful attacks, especially elicited by exposure to cold 3) generally occur as solitary subungual tumors 4) may occur as multiple papules or nodules (glomangiomas) a) glomangioma do not occur underneath the nail b) may occur anywhere on the skin surface c) largely vascular rather than solid as a solitary lesions 5) may also be found on the tympanic membrane (glomus tympanicum)

Related

glomulin (GLMN FK506-binding protein-associated protein, 48 kD)

Specific

aural glomus tumor; glomus tympanicum glomus jugulare tumor; jugulotympanic paraganglioma

General

pericytic neoplasm

References

  1. Color Atlas and Synopsis of Clinical Dermatology, Common and Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY, 1997, pg 161
  2. UniProt :accession Q92990
  3. Wikipedia: Glomus tumor http://en.wikipedia.org/wiki/Glomus_tumor

Databases & Images

OMIM 138000 images related to glomangioma