glitazar

Mechanism of action: 1) so-called 2 in 1 drugs. a) improve blood glucose similar to thiazolidinediones b) improve lipid profile similar to fibrates 2) activates both PPAR-alpha & PPAR-gamma a) activation of PPAR-gamma decreases plasma glucose & free fatty acid concentrations b) activation of PPAR-alpha receptors decreases plasma triglyceride & increases plasma HDL cholesterol

Interactions

drug interactions drug adverse effects of hypoglycemic agents

Specific

muraglitazar (Pargluva) tesaglitazar (Galida)

General

oral hypoglycemic agent peroxisome proliferator; PPAR agonist; PPAR gamma agonist

References

- Prescriber's Letter 12(9): 2005 Diabetes Drugs on the Horizon: Investigational Drug: Muraglitazar (Pargluva) Detail-Document#: 210905 (subscription needed) http://www.prescribersletter.com