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gli-1 proto-oncogene protein; glioma associated transforming protein gli1; zinc finger protein GLI1 (GLI1, GLI)
Function:
- may regulate the transcription of specific genes during normal development
- may play a role in craniofacial development & digital development, central nervous system development & gastrointestinal tract development
- mediates SHH signaling & thus cell proliferation & differentiation
- implicated in transduction of sonic hedgehog signalling
Structure:
- belongs to the GLI C2H2-type Zn+2-finger protein family
- contains 5 C2H2-type Zn+2 fingers
Compartment:
- cytoplasm, nucleus
- tethered in the cytoplasm by binding to SUFU
- activation & translocation to the nucleus is promoted by interaction with STK36
Expression:
- testis, myometrium & fallopian tube
Pathology:
- defects in GLI1 may be a cause of breast cancer
- amplified in glioblastoma cells
Related
gli-1 proto-oncogene
General
C2H2 type zinc finger protein
GLI-Krueppel family protein
Properties
SIZE: entity length = 1106 aa
MW = 118 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 235-260
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 268-295
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 301-325
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 331-356
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 362-387
EFFECTOR-BOUND: Zn+2
acidic region {1038-1055}
MOTIF: acidic residue (SEVERAL)
References
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147
- Entrez Gene :accession 2735
- Atlas of genetics & cytogenetics in oncology & haematology
- UniProt :accession P08151
Databases & Figures
OMIM 165220
UniProt P08151
Entrez Gene 2735
hedgehog/gli pathway