Contents

Search

Gleason scoring system for prostate cancer

Grading ranges from: 1 (more differentiated) to 5 (less differentiated) More than 1 pattern may be present in a surgical specimen. The 2 predominant histological patterns are graded individually, then added for a final Gleason score. For example, 3 + 4 = 7. Thus, the scores range from 2-10. Grades: (individual histopathology patterns) [3] 1) small uniform cells 2) more space between cells 3) infiltration of cells from glands at margins 4) irregular masses of cells with few glands 5) lack of glands, sheets of cells Gleason score: 1) 2-6: low grade or well-differentiated tumor 2) 7: moderate-grade or moderately differentiated tumor 3) 8-10: high-grade or poorly differentiated tumor Final grades 2-6 are associated with a better prognosis. 15 year mortality from prostate cancer by Gleason score Gleason score 15 year mortality 2-5 4-11% 6 20-30% 7 40-70% 8-10 60-90%

General

numerical rating scale (NRS)

References

  1. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 675
  2. Aronson WJ, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  3. Quiz: Do You Know the Current Guidelines for the Screening and Treatment of Prostate Cancer? Medscape. Jul 24, 2014