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PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Tax interaction protein 2; TIP-2 (GIPC1, C19orf3, GIPC, RGS19IP1)
Function:
- may be involved in G protein-linked signaling
- interacts with GLUT1 (C-terminus), ACTN1, KIF1B, MYO6, PLEKHG5, SDC4/syndecan-4 & SEMA4C/semaphorin-4C (putative)
- interacts with RGS19 C-terminus.
- interacts with HTLV-I Tax through the PDZ domain
Structure:
- belongs to the GIPC family
- contains 1 PDZ domain (DHR domain)
Compartment:
- cytoplasm, peripheral membrane
Expression: widely expressed
General
other protein
Properties
SIZE: entity length = 333 aa
MW = 36 kD
COMPARTMENT: cytoplasm
MOTIF: glycine-rich region {36-42}
proline-rich region
SITE: 48-52
MOTIF: proline residue (SEVERAL)
PDZ domain
NAME: PDZ domain
SITE: 133-213
Database Correlations
OMIM 605072
UniProt O14908
Pfam PF00595
Entrez Gene 10755
Kegg hsa:10755
References
UniProt :accession O14908