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Gi-protein
Function:
- second messengers relaying signals from G-protein-coupled receptors (serpentine receptors)
- inhibits adenyl cyclase (see Gi-alpha)
- phosphorylation of MAP kinases
Structure:
- Gi-alpha - G-beta/gamma - GDP/GTP complex
Interactions
molecular events
General
G-protein
Properties
COMPARTMENT:
plasma membrane*
CELL: most cell types*
ORGANISM: eukaryote*
MOTIF:
Mg+2-binding site
SUBUNITS:
Gi-alpha
MOTIF: binding site
EFFECTOR-BOUND: G-beta/gamma
P-loop
EFFECTOR-BOUND: guanosine triphosphate
Mg+2-binding site
Ser phosphorylation site
guanine nucleotide-binding site
EFFECTOR-BOUND: guanosine diphosphate
ADP-ribosylation site
ADP-ribosylation site {C350}
GTP-binding regulatory protein beta
MOTIF: WD repeat (8)
membrane region
Ser phosphorylation site
guanine nucleotide binding protein (G protein), gamma subunit
MOTIF: CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: prenyl
BOUND-VIA: cysteine residue
References
- Bourne HR et al,
The GTPase superfamily: a conserved switch for diverse cell
functions
Nature 348:125 1990
PMID: 2122258
- UniProt :accession Q9BPV8
Components
G-beta/gamma
Gi-alpha
GTP-binding regulatory protein beta
guanine nucleotide binding protein (G protein), gamma subunit