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gastrointestinal (GI) cancer

Cancers of the gastrointestinal (GI) tract. Inconclusive data on antioxidants in prevention of GI cancers. [1,2] Complications: - cardiac disease is a significant cause of mortality - treatment with chemotherapy, radiation therapy or both is associated with higher cardiac mortality [5]

Interactions

disease interactions

Related

biliary carcinoma liver cancer; hepatobiliary carcinoma pancreatic cancer

Specific

anal cancer colorectal cancer esophageal cancer gastric cancer gastroesophageal junction cancer/adenocarcinoma gastrointestinal stromal tumor (GIST) rectal carcinoma small intestinal cancer

General

malignant neoplasm of digestive organs & peritoneum

References

  1. Journal Watch 24(22):170, 2004 Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet. 2004 Oct 2;364(9441):1219-28. Review. PMID: 15464182
  2. Bjelakovic G, Nikolova D, Simonetti R, Gluud C. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004183. PMID: 15495084
  3. Syngal S, Brand RE, Church JM et al ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015 Feb;110(2):223-62; Review. PMID: 25645574 Free PMC Article
  4. ARUP consult: Hereditary Gastrointestinal Cancer Panel, Including Lynch Syndrome. https://arupconsult.com/ati/Hereditary-Gastrointestinal-Cancer-Panel
  5. Ramai D, Heaton J, Ghidini M et al Population-Based Long-term Cardiac-Specific Mortality Among Patients With Major Gastrointestinal Cancers. JAMA Netw Open. 2021;4(6):e2112049. June 17 PMID: 34137831 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2781184