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glial fibrillary acidic protein (GFAP) in blood/plasma/serum

Indications: - assessment of need for CT of brain in adults with mild traumatic brain injury (concussion) Clinical significance: - released from the brain into blood - can be measured within 12 hours of head injury - higher plasma GFAP is associated with higher risk of cardiovascular disease, mortality from heart failure, & kidney disease [2] - 5x higher concentrations of serum GFAP associated with increased risk of overall mortality (RR=1.43) [3] Method: - 3-4-hour turnaround time

Related

glial fibrillary acidic protein; GFAP (GFAP) ubiquitin C-terminal hydrolase in blood

General

special chemistry test

References

  1. Brooks M FDA Clears First Blood Test to Aid in Concussion Diagnosis. Medscape - Feb 14, 2018. https://www.medscape.com/viewarticle/892683 - FDA News Release. Feb 14, 2018 FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm596531.htm
  2. Dark HE, Paterson C, Daya GN et al Proteomic Indicators of Health Predict Alzheimer's Disease Biomarker Levels and Dementia Risk. Ann Neurol. 2023. Oct 6. PMID: 37801487 https://onlinelibrary.wiley.com/doi/full/10.1002/ana.26817
  3. Halloway S et al Serum total tau, neurofilament light, and glial fibrillary acidic protein are associated with mortality in a population study. J Am Geriatr Soc. 2024 Jan;72(1):149-159 PMID: 37818793 https://agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/jgs.18632