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germinal center B-cell lymphoma
Pathology:
- most B-cell lymphomas orginate from germinal centers
- BCL6 transcription factor plays a central role in establishing the germinal cell phenotype in B cells
- most lymphomas are dependent on BCL6 to maintain survival, proliferation, & immune evasion [1]
Management:
- R-CHOP* is generally standard of care when treatment is indicated
* rituximab/cyclophosphamide/doxorubicin/vincristine/prednisone
General
B-cell lymphoid neoplasm (B-cell lymphoma)
References
- Mlynarczyk C, Fontan L, Melnick A.
Germinal center-derived lymphomas: The darkest side of humoral immunity.
Immunol Rev. 2019 Mar;288(1):214-239.
PMID: 30874354 PMCID: PMC6518944 Free PMC article. Review.