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gepotidacin
Indications:
- treatment of complicated urinary tract infections (UTIs)
* non-inferior to nitrofurantoin for treatment of uncomplicated UTIs
Dosage:
- 1500 mg PO BID for 5 days
Adverse effects:
- diarrhea (14%)
Antimicrobial activity:
- common uropathogens, including clinically important drug-resistant organisms
Mechanism of action:
- inhibits bacterial DNA replication
- inhibition of two type II topoisomerase enzymes
General
other antibiotic
References
- Wagenlehner F, Perry CR, Hooton TM et al
Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract
infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-
dummy, phase 3, non-inferiority trials.
Lancet. 2024 Feb 8:S0140-6736(23)02196-7.
PMID: 38342126