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geographic atrophy
Etiology:
- macular degeneration
- advanced dry form of age-related macular degeneration
Epidemiology:
- affects > 1 million people in the U.S. & 5 million people worldwide
Complications:
- major cause of adult blindness
Management:
- pegcetacoplan (Syfovre) injection administered every 25-60 days (FDA-approved)
- maximum benefit between 18-24 months after initiating treatment.
- avacincaptad pegol (Izeray)
- photovoltaic retina implant microarray (PRIMA) system
- combines a subretinal photovoltaic implant & glasses that project near-infrared light to the implant in order to restore sight to areas of central retinal atrophy [2]
General
retinal disease
References
- Marcus A
FDA OKs First Drug for Geographic Atrophy, a Major Cause of Adult Blindness.
Medscape. February 17, 2023
https://www.medscape.com/viewarticle/988460
- Holz FG, Le Mer Y, Muqit MMK et al
Subretinal Photovoltaic Implant to Restore Vision in Geographic Atrophy Due to AMD.
NEJM 2025 October 20
Not yet indexed in PubMed
https://www.nejm.org/doi/full/10.1056/NEJMoa2501396
- Drew L
People with blindness can read again after retinal implant.
Nature News. 2025. Oct 20.
https://www.nature.com/articles/d41586-025-03420-x