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gentian violet; crystal violet; methylrosaniline
In laboratory medicine:
Uses:
used as a stain for:
1) chromatin
2) amyloid
3) platelets
4) fibrin
5) bacteria
6) neuroglia
Pharmacology:
Indications:
1) topical treatment of fungal infections of the skin & mucous membranes
2) topical treatment of burns
3) topical treatment of wounds
4) oral treatment of pinworms & trematode infections
5) topical treatment of cutaneous T-cell lymphoma ? [3]
Contraindications: Caution:
- avoid coitus when used for vaginal candidiasis
Dosage:
1) apply to affected area BID-TID for 3 days
2) avoid occlusion of infected areas
3) do NOT swallow
4) infants: 3-4 drops of 0.5% solution under tongue or onto lesion after feeding
Solution: 1%, 2% (30 mL).
Antimicrobial activity:
- Candida albicans
- Epidermophyton
- Cryptococcus
- Trichophyton
- Geotrichum candidum
- Staphylococcus
Adverse effects:
1) not common (1-10%)
- esophagitis, burning, irritation, vesicle formation, hypersensitivity, mucous membrane ulceration, laryngitis, tracheitis, laryngeal obstruction, tattooing of granulation tissue
2) other
- stains skin & clothing purple
Interactions
drug interactions
Related
crystal violet staining
microscopic observation in tissue by crystal violet stain
General
antifungal agent
pigment
other antibiotic
Properties
Database Correlations
PUBCHEM correlations
References
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
- Wu J, Wood GS.
Analysis of the Effect of Gentian Violet on Apoptosis and
Proliferation in Cutaneous T-Cell Lymphoma in an In Vitro
Study.
JAMA Dermatol. Published online August 29, 2018.
PMID: 30167641
https://jamanetwork.com/journals/jamadermatology/fullarticle/2697566
Component-of
brilliant green/gentian violet
brilliant green/gentian violet/proflavine