general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; STAF97 (GCN5L2, GCN5, HGCN5, KAT2A)

Function: - histone acetyltransferase - promotes transcriptional activation - acetylation of histones gives a specific tag for epigenetic transcription activation - has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles - interacts with EP300, CREBBP & ADA2 - component of the TFTC-HAT complex - interacts with TRRAP. component of the STAGA transcription coactivator-HAT complex Structure: - belongs to the GCN5 family - contains 1 bromo domain - contains 1 N-acetyltransferase domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - expressed in all tissues tested - most abundant expression in ovary Pathology: - in case of HIV-1 infection, GCN5L2 is recruited by the retroviral protein Tat - regulates Tat's transactivating activity & may help inducing chromatin remodeling of proviral genes - interacts with & acetylates HIV-1 Tat

General

histone acetyltransferase phosphoprotein

Properties

SIZE: entity length = 837 aa MW = 94 kD COMPARTMENT: cell nucleus MOTIF: N-acetyltransferase {503-656} Tyr phosphorylation site {Y734} bromodomain {745-815}

Database Correlations

OMIM 602301 UniProt Q92830 PFAM correlations Entrez Gene 2648 Kegg hsa:2648 ENZYME 2.3.1.48

References

UniProt :accession Q92830