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transcription factor 9; GC-rich sequence DNA-binding factor; GCF; GC-rich sequence DNA-binding factor (TCF9, GCFC2, C2orf3)
Function:
- factor that represses transcription
- binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, & Ca+2-dependent protease promoters
Structure: belongs to the GCF family
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: widely expressed in tissues & cell lines
General
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: entity length = 781 aa
MW = 89 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S16}
Ser phosphorylation site {S17}
Ser phosphorylation site {S19}
Ser phosphorylation site {S96}
Thr phosphorylation site {T97}
serine-rich region {116-122}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S129}
Ser phosphorylation site {S180}
coiled coil {267-312}
Ser phosphorylation site {S429}
Ser phosphorylation site {S430}
Database Correlations
OMIM 189901
UniProt P16383
Pfam PF07842
Kegg hsa:6936
References
UniProt :accession P16383