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GTP-binding regulatory protein beta-5; transducin beta-5 (GNB5)
Function:
- G-beta & G-gamma chains are required for
a) GTPase activity of heterotrimeric G proteins
b) replacement of GDP by GTP
c) G protein-effector interaction
- component of the RGS9-1-Gbeta5 complex composed of RGS9 (isoform RGS9-1), Gbeta5 (GNB5) & RGS9BP (putative)
Structure:
- G proteins are composed of 3 units G-alpha, G-beta & G-gamma
- belongs to the WD repeat G protein beta family
- contains 7 WD repeats
Alternative splicing: named isoforms=2
Expression: expressed in multiple tissues
Related
G-beta/gamma
G-protein
General
GTP-binding regulatory protein beta
Properties
SIZE: entity length = 395 aa
MW = 44 kD
MOTIF: WD repeat {103-142}
WD repeat {145-184}
WD repeat {193-234}
WD repeat {236-278}
WD repeat {279-318}
WD repeat {320-362}
WD repeat {365-394}
Database Correlations
OMIM 604447
UniProt O14775
Entrez Gene 10681
Kegg hsa:10681
References
UniProt :accession O14775
Component-of
R7-Gbeta5 complex