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GATA binding factor-4; transcription factor GATA-4 (GATA4)
Function:
- transcriptional activator
- binds to consensus sequence 5'-AGATAG-3'
- acts as a transcriptional activator of ANF in cooperation with NKX2-5 (putative)
- promotes cardiac myocyte enlargement
- methylation at Lys-300 attenuates transcriptional activity
- interacts with ZNF260 (putative)
- interacts with homeobox domain of NKX2-5 through its C-terminal Zn+2 finger
- interaction with JARID2 represses its ability to activate transcription of ANF (putative)
- interacts with NFATC4 & LMCD1
- forms a complex with CDK9, CCNT1/cyclin-T1, & EP300 that stimulates hypertrophy in cardiomyocytes
Structure: contains 2 GATA-type Zn+2 fingers
Compartment: nucleus
Pathology:
- defects in GATA4 are the cause of
a) atrial septal defect type 2
b) atrioventricular septal defect type 4
- defects in GATA4 are a cause of
a) ventricular septal defect type 1
b) tetralogy of Fallot
General
GATA binding factor (transcription factor GATA)
human longevity protein
phosphoprotein
Properties
SIZE: entity length = 442 aa
MW = 45 kD
COMPARTMENT: cell nucleus
MOTIF: alanine-rich region {118-126}
MOTIF: alanine residue (SEVERAL)
alanine-rich region {174-181}
MOTIF: alanine residue (SEVERAL)
Zn finger GATA-type
SITE: 217-241
EFFECTOR-BOUND: Zn+2
Zn finger GATA-type
SITE: 271-295
EFFECTOR-BOUND: Zn+2
MOTIF: threonine-rich region {276-280}
MOTIF: threonine residue (SEVERAL)
Ser phosphorylation site {S406}
Database Correlations
OMIM correlations
MORBIDMAP 600576
UniProt P43694
PFAM correlations
Entrez Gene 2626
Kegg hsa:2626
References
- UniProt :accession P43694
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA4