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GATA binding factor-3; T-cell transcription factor GATA-3; trans-acting T-cell-specific transcription factor GATA-3 (GATA3)
Function:
- transcriptional activator
- binds to the enhancer of the T-cell receptor alpha & T-cell receptor delta genes
- binds to the consensus sequence 5'-AGATAG-3'
Structure: contains 2 GATA-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: -expressed in T-cells & endothelial cells
Pathology:
- defects in GATA3 are the cause of Barakat syndrome
General
GATA binding factor (transcription factor GATA)
Properties
SIZE: entity length = 443 aa
MW = 48 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {137-142}
MOTIF: serine residue (SEVERAL)
Zn finger GATA-type
SITE: 263-287
EFFECTOR-BOUND: Zn+2
Zn finger GATA-type
SITE: 317-341
EFFECTOR-BOUND: Zn+2
MOTIF: threonine-rich region {322-326}
MOTIF: threonine residue (SEVERAL)
Database Correlations
OMIM correlations
MORBIDMAP 131320
UniProt P23771
Pfam PF00320
Entrez Gene 2625
Kegg hsa:2625
References
- UniProt :accession P23771
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GATA3
- SeattleSNPs
http://pga.gs.washington.edu/data/gata3/