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GATA binding factor-2; endothelial transcription factor GATA-2 (GATA2)
Function:
- transcriptional activator
- regulates endothelin-1 gene expression in endothelial cells
- binds to the consensus sequence 5'-AGATAG-3'
Structure: contains 2 GATA-type Zn+2 fingers
Compartment: nucleus
Expression: endothelial cells
Pathology:
- haploinsufficiency of GATA2 results in GATA2 deficiency
General
GATA binding factor (transcription factor GATA)
Properties
SIZE: entity length = 480 aa
MW = 50 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger GATA-type
SITE: 295-319
EFFECTOR-BOUND: Zn+2
Zn finger GATA-type
SITE: 349-373
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 137295
UniProt P23769
Pfam PF00320
Entrez Gene 2624
References
UniProt :accession P23769