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gastrin in serum
Normal range:
1) 25-90 pg/mL [1]
2) < 180 pg/mL [2]
Clinical significance:
- gastrin levels follow a circadian pattern
- they are lowest at 0300-0700 hours & highest during the day or fluctuate in relation to meals
- see Increases:
Increases:
1) Zollinger Ellison syndrome
a) most have fasting levels > 500 pg/mL
b) 40% have fasting levels 100-500 pg/mL
2) antral G-cell hyperplasia
3) pyloric obstruction
4) vagotomy without gastric resection
5) retained antrum
6) chronic atrophic gastritis
- gastric carcinoid
7) pernicious anemia
8) chronic renal failure
9) gastric carcinoma
10) gastric ulcer
11) pharmaceutical agents
a) oral amino acids
b) calcium carbonate
c) calcium chloride (IV)
d) catecholamines
e) cimetidine
f) coffee
g) insulin
h) proton pump inhibitors
1] omeprazole (Prilosec)
2] lansoprazole (Prevacid)
3] pantoprazole (Protonix)
4] rabeprazole (Aciphex)
Decreases:
1) antrectomy with vagotomy
2) hypothyroidism
3) pharmaceutical agents
a) atropine
b) secretin
Specimen:
1) patient preparation:
-> stop proton-pump inhibitors for 5 days prior to measurement of serum gastrin
2) fasting
3) serum
4) freeze immediately, store at -70 degrees C
Related
gastrin (GAST, GAS)
Specific
gastrin 14 residue fragment in serum
gastrin 17 residue fragment in serum
gastrin 34 residue fragment in serum
gastrin in serum post secretin stimulation
General
special chemistry test
References
- Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz
ed, WB Saunders, Philadelphia, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 11, 17.
American College of Physicians, Philadelphia 1998, 2015
- Gastrin
Laboratory Test Directory ARUP: 70075