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growth arrest-specific protein 7; GAS-7 (GAS7 KIAA0394)
Function:
- may play a role in promoting maturation & morphological differentiation of cerebellar neurons
Structure:
- contains 1 FCH domain
- contains 1 SH3 domain
- contains 1 WW domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=3
Pathology:
- chromosomal translocation t(11;17)(q23;p13) involving GAS7 with MLL/HRX is a cause of acute myeloid leukemia
General
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 476 aa
MW = 54 kD
COMPARTMENT: cytoplasm
MOTIF: src homology 3 [SH3] domain
SITE: 1-62
proline-rich region
SITE: 67-70
MOTIF: proline residue (SEVERAL)
WW domain (W/rsp5/WWP domain) {77-110}
Ser phosphorylation site {S117}
FCH domain {196-288}
coiled coil {309-419}
Database Correlations
OMIM 603127
UniProt O60861
PFAM correlations
Kegg hsa:8522
References
- UniProt :accession O60861
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GAS7ID257.html