Gardner's syndrome

variant of familial adenomatous polyposis Pathology: - dental anomalies - jaw cysts - epidermoid cysts & sebaceous cysts, especially of the face & scalp - fibromas - lipomas - osteomas - adrenal adenoma - ovarian tumors - desmoid tumor - congenital hypertrophy of the retinal pigment epithelium (CHRPE) (90%) (see OMIM 175100) Genetics: same mutations as familial adenomatous polyposis

Properties

ASSOCIATED-NEOPLASM[S]: colorectal adenomatous polyp :SITE gastrointestinal system adenocarcinoma of the colon hepatoblastoma exostosis fibroma osteosarcoma adrenal cortical carcinoma thyroid carcinoma DESMOID bile duct cancer epidermoid cyst