gamma-glutamyltransferase (GGT) or gamma-glutamyltranspeptidase

Function: - plasma membrane enzyme may be involved in amino acid transport (see gamma-glutamyl cycle) Compartment: - present in plasma membrane & microsomal fractions Expression: - hepatic tissue levels increase in response to microsomal enzyme induction Pathology: - elevated serum levels observed in patients with hepatobiliary disease Laboratory: - gamma-glutamyltransferase in body fluid - gamma-glutamyltransferase in amniotic fluid - gamma-glutamyltransferase in dialysis fluid - gamma-glutamyltransferase in semen - gamma-glutamyltransferase in serum - gamma-glutamyltransferase in urine

Related

gamma glutamyl cycle gamma-glutamyltransferase (GGT) in serum gamma-glutamyltransferase-like protein

Specific

gamma-glutamyltransferase 6 (gamma-glutamyltranspeptidase 6, GGT 6, [contains: gamma-glutamyltransferase 6 heavy chain; gamma-glutamyltransferase 6 light chain], GGT6) gamma-glutamyltransferase 7; GGT 7;gamma-glutamyltransferase-like 3; gamma-glutamyltransferase-like 5; gamma-glutamyltranspeptidase 7; contains: gamma-glutamyltransferase 7 heavy chain; gamma-glutamyltransferase 7 light chain (GGT7, GGTL3, GGTL5) gamma-glutamyltransferase light chain 3 (GGTLC3) gamma-glutamyltransferase-1 (GGT1, gamma-glutamyltranspeptidase-1, CD224 antigen) gamma-glutamyltransferase-2 (GGT2, gamma-glutamyltranspeptidase-2) gamma-glutamyltransferase-5 (GGTLA1, GGT5)

General

glutamyltransferase multisubunit protein plasma membrane protein

Properties

MOTIF: membrane region active site MISC-INFO: lifetime 3-7 HOURS {1/2-LIFE}

References

Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 263