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cyclin-G-associated kinase (GAK)
Function:
- associates with cyclin G & CDK5
- seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells
ATP + a protein = ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family
- contains 1 C2 tensin-type domain
- contains 1 J domain
- contains 1 phosphatase tensin-type domain
- contains 1 protein kinase domain
Compartment:
- cytoplasm, perinuclear region
- Golgi, trans-Golgi network
- cell junction, focal adhesion (probable)
Expression:
- ubiquitous
- highest in testis
- expression oscillates slightly during the cell cycle, peaking at G1
General
serine/threonine kinase
Properties
SIZE: entity length = 1311 aa
MW = 143 kD
COMPARTMENT: cytoplasm
cell nucleus
golgi
STATE: active state
MOTIF: Ser phosphorylation site {S16}
kinase domain
SITE: 40-314
MOTIF: ATP-binding site
NAME: ATP-binding site
aspartate residue {D173}
Ser phosphorylation site {S326}
proline-rich region
SITE: 347-350
MOTIF: proline residue (SEVERAL)
Phosphatase tensin-type {399-566}
MOTIF: Ser phosphorylation site {S456}
C2 tensin-type {572-710}
MOTIF: Tyr phosphorylation site {Y615}
Ser phosphorylation site {S770}
Thr phosphorylation site {T776}
Ser phosphorylation site {S778}
Ser phosphorylation site {S780}
Thr phosphorylation site {T805}
Ser phosphorylation site {S815}
Ser phosphorylation site {S817}
Ser phosphorylation site {S826}
Ser phosphorylation site {S829}
Ser phosphorylation site {S834}
Ser phosphorylation site {S837}
Ser phosphorylation site {S838}
Ser phosphorylation site {S939}
Ser phosphorylation site {S1070}
Ser phosphorylation site {S1073}
Ser phosphorylation site {S1096}
Ser phosphorylation site {S1176}
Ser phosphorylation site {S1185}
J domain {1247-1311}
Database Correlations
OMIM 602052
UniProt O14976
PFAM correlations
Entrez Gene 2580
Kegg hsa:2580
ENZYME 2.7.11.1
References
UniProt :accession O14976