viral Group-specific AntiGen [GAG] protein

Precursor cleaved to yield capsid proteins. (Group-specific AntiGen ==> GAG) Contains: Matrix protein p17 (MA) Capsid protein p24 (CA) Spacer peptide p2 Nucleocapsid protein p7 (NC) Spacer peptide p1; p6-gag] Function: 1) orchestrated tasks during assembly, budding, maturation, infection stages of the viral replication cycle 2) during viral assembly, the proteins form membrane associations & self-associations that ultimately result in budding of an immature virion from the infected cell 3) during viral assembly to selectively binds & packages 2 plus strands of genomic RNA 4) endogenous Gag proteins may have kept, lost or modified their original function during evolution.

General

retroviridae protein viral core protein

Database Correlations

SWISS-PROT correlations PFAM correlations

References

Watson et al Molecular Biology of the Gene, Benjamin Cummings, Menlo Park, CA 1987, pg 937