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growth arrest & DNA-damage-inducible protein GADD45 gamma; cytokine-responsive protein CR6; DNA-damage-inducible transcript 2; DDIT-2 (GADD45G CR6 DDIT2)

Function: - role in the regulation of growth & apoptosis - mediates activation of stress-responsive MTK1/MEKK4 MAPKKK interacts with GADD45GIP1 - GADD45A, GADD45B & GADD45G bind to N-terminal domain of Mtk1 & activate Mtk1 kinase activity. Structure: belongs to the GADD45 family

General

growth arrest & DNA-damage inducible-45 (GADD45)

Properties

SIZE: entity length = 159 aa MW = 17 kD COMPARTMENT: cell nucleus MOTIF: binding site FOR-BINDING-OF: proliferating cell nuclear antigen

Database Correlations

OMIM 604949 UniProt O95257 Pfam PF01248 Entrez Gene 10912 Kegg hsa:10912

References

  1. UniProt :accession O95257
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/gadd45g/