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growth arrest & DNA-damage-inducible protein GADD45 beta; myeloid differentiation primary response protein MyD118; negative growth regulatory protein MyD118 (GADD45B, MYD118)
Function:
- role in the regulation of growth & apoptosis
- mediates activation of stress-responsive MTK1/MEKK4 MAPKKK
- GADD45A, GADD45B & GADD45G bind to N-terminal domain of Mtk1 & activate Mtk1 kinase activity
- interacts with GADD45GIP1
Structure: belongs to the GADD45 family
General
growth arrest & DNA-damage inducible-45 (GADD45)
Properties
SIZE: entity length = 160 aa
MW = 18 kD
COMPARTMENT: cell nucleus
MOTIF: binding site
FOR-BINDING-OF: proliferating cell nuclear antigen
Database Correlations
OMIM 604948
UniProt O75293
Pfam PF01248
Entrez Gene 4616
Kegg hsa:4616
References
- UniProt :accession O75293
- NIEHS-SNPs
http://egp.gs.washington.edu/data/gadd45b/
- Takekawa M & Saito H
A family of stress-inducible GADD45-like proteins mediate
activation of the stress-responsive MTK1/MEKK4 MAPKKK.
Cell 95:521-30, 1998
PMID: 9827804