Contents

Search

growth arrest & DNA-damage-inducible protein GADD45 alpha; GAD45-alpha; DNA-damage-inducible transcript 1; DDIT-1 (GADD45A, DDIT1, GADD45)

The 45 presumably reflects apparent molecular weight. Function: - binds to proliferating cell nuclear antigen - might affect PCNA interaction with some CDK (cell division protein kinase) complexes - binding of GADD45A to PCNA may displace PCNA from CDK complexes - stimulates DNA excision repair in vitro & inhibits entry of cells into S phase - GADD45A, GADD45B & GADD45G bind to N-terminal domain of Mtk1 & activate Mtk1 kinase activity. - interacts with GADD45GIP1 Structure: belongs to the GADD45 family Expression: - induced by UV radiation, X-rays, growth arrest & alkylating agents - induction is mediated by some kinase(s) other than PKC Pathology: - induction of GADD45 in ataxia telangiectasia cells is abnormal

General

growth arrest & DNA-damage inducible-45 (GADD45)

Properties

SIZE: entity length = 165 aa MW = 18 kD COMPARTMENT: cell nucleus MOTIF: binding site FOR-BINDING-OF: proliferating cell nuclear antigen

References

  1. UniProt :accession P24522
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/gadd45a/
  3. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376-80. PMID: 7973727

Databases & Figures

OMIM 126335 UniProt P24522 Pfam PF01248 Entrez Gene 1647 Kegg hsa:1647 p53 -> cell cycle