gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1 (GABRR1)

Function: - GABA-A receptor subunit - Rho-1 GABA receptor could play a role in retinal neurotransmission - interacts with SQSTM1 (putative) Structure: - belongs to the ligand-gated ionic channel (TC 1.A.9) family Compartment: - cell junction, synapse, postsynaptic cell membrane Expression: - highly expressed in the retina - expressed to a lesser extent in brain, lung & thymus

General

gamma-aminobutyric acid (GABA) A receptor, rho transmembrane 4e protein

Properties

SIZE: entity length = 473 aa MW = 55 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {11-275} MOTIF: signal sequence {1-15} N-glycosylation site {N134} cysteine residue {C192} MODIFICATION: cysteine residue {C206} cysteine residue {C206} MODIFICATION: cysteine residue {C192} N-glycosylation site {N228} N-glycosylation site {N268} transmembrane domain {276-299} cytoplasmic loop {300-302} transmembrane domain {303-325} exoplasmic loop {326-336} transmembrane domain {337-359} cytoplasmic loop {360-451} transmembrane domain {452-473} exoplasmic domain {473-473}

Database Correlations

OMIM 137161 UniProt P24046 PFAM correlations Entrez Gene 2569 Kegg hsa:2569

References

UniProt :accession P24046