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gamma-aminobutyric acid receptor subunit beta-2; GABA(A) receptor subunit beta-2 (GABRB2)
Function:
- GABA-A receptor beta subunit
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment: cell junction, synapse, postsynaptic cell membrane
Alternative splicing: named isoforms=2
General
gamma-aminobutyric acid (GABA) A receptor, beta
glycoprotein
transmembrane 4e protein
Properties
SIZE: entity length = 474 aa
MW = 55 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {26-244}
MOTIF: signal sequence {1-25}
N-glycosylation site {N32}
N-glycosylation site {N104}
cysteine residue {C160}
MODIFICATION: cysteine residue {C174}
N-glycosylation site {N173}
cysteine residue {C174}
MODIFICATION: cysteine residue {C160}
transmembrane domain {245-266}
cytoplasmic loop {267-269}
transmembrane domain {270-292}
exoplasmic loop {293-303}
transmembrane domain {304-326}
cytoplasmic loop {327-451}
MOTIF: Tyr phosphorylation site {Y396}
Tyr phosphorylation site {Y403}
transmembrane domain {452-473}
exoplasmic domain {473-474}
Database Correlations
OMIM 600232
UniProt P47870
PFAM correlations
Entrez Gene 2561
Kegg hsa:2561
References
- UniProt :accession P47870
- Protein Spotlight; Note: forbidden fruit -
Issue 56 of March 2005
http://www.expasy.org/spotlight/back_issues/sptlt056.shtml