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gamma-aminobutyric acid receptor subunit alpha-2; GABA(A) receptor subunit alpha-2 (GABRA2)
Function:
- GABA-A receptor alpha subunit
- binds UBQLN1 (putative)
- anxiolytic benzodiazepine receptor may depend upon GABA-A receptor alpha-2.
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment:
- cell junction, synapse, postsynaptic cell membrane
Polymorphism:
- genetic variations in GABRA2 determine the genetic susceptibility to alcoholism [4]
General
gamma-aminobutyric acid (GABA) A receptor, alpha
glycoprotein
transmembrane 4e protein
Properties
SIZE: entity length = 451 aa
MW = 51 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-251}
MOTIF: signal sequence {1-28}
N-glycosylation site {N38}
N-glycosylation site {N138}
cysteine residue {C166}
MODIFICATION: cysteine residue {C180}
cysteine residue {C180}
MODIFICATION: cysteine residue {C166}
transmembrane domain {252-273}
cytoplasmic loop {274-278}
transmembrane domain {279-300}
exoplasmic loop {301-312}
transmembrane domain {313-334}
cytoplasmic loop {335-419}
transmembrane domain {420-441}
exoplasmic domain {442-451}
Database Correlations
OMIM correlations
MORBIDMAP 137140
UniProt P47869
PFAM correlations
Entrez Gene 2555
Kegg hsa:2555
References
- UniProt :accession P47869
- Protein Spotlight; Note: forbidden fruit -
Issue 56 of March 2005
http://www.expasy.org/spotlight/back_issues/sptlt056.shtml
- Journal Watch 20(22):176, 2000
Low K, Crestani F, Keist R, Benke D, Brunig I et al
Molecular and neuronal substrate for the selective attenuation
of anxiety.
Science. 2000 Oct 6;290(5489):131-4.
Erratum in: Science 2000 Nov 3;290(5493):936c.
PMID: 11021797
- OMIM :accession 103780