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GABA-A receptor
Function:
- ionotropic receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain
- mediates neuronal inhibition through its integral chloride channel
Pathology:
- GABA-A receptor antibody encephalitis
Interactions
molecular events
General
Cl- channel
gamma amino butyric acid [GABA] receptor
ionotropic receptor
multisubunit protein
phosphoprotein
Properties
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: ligand-binding site
membrane region
ION-PERMEABILITY: Cl-
HCO3-
SUBUNITS: GABA-A receptor alpha
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
glycosylation site {N-TERMINAL}
ligand-binding site
transmembrane domain {TM1}
cytoplasmic loop
LOOP#: 1
transmembrane domain {TM2}
exoplasmic loop
transmembrane domain {TM3}
cytoplasmic loop
MOTIF: S/T phosphorylation site
LOOP#: 2
transmembrane domain {TM4}
exoplasmic domain {C-TERMINAL}
GABA-A receptor beta
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
glycosylation site {N-TERMINAL}
ligand-binding site
transmembrane domain {TM1}
cytoplasmic loop
LOOP#: 1
transmembrane domain {TM2}
exoplasmic loop
transmembrane domain {TM3}
cytoplasmic loop
MOTIF: S/T phosphorylation site
LOOP#: 2
transmembrane domain {TM4}
exoplasmic domain {C-TERMINAL}
MISC-INFO: LIGAND = MUSCIMOL
LIGAND = BACLOFEN
INHIBITOR = BICUCULLINE
Components
gamma-aminobutyric acid (GABA) A receptor, alpha
gamma-aminobutyric acid (GABA) A receptor, beta
gamma-aminobutyric acid receptor subunit rho-3 (GABA(A) receptor subunit rho-3, GABRR3)