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GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1 (GAB1)

Function: - adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-tyrosine kinases - plays a role in FGFR1 signaling - probably involved in signaling by EGF receptor (EGFR) & insulin receptor (INSR) - phosphorylated in response to FGFR1 activation - phosphorylated on Tyr by EGFR & INSR - Tyr phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains - phosphorylated on Tyr by HCK upon IL6 signaling - interacts with GRB2 & with other SH2-containing proteins - interacts with phosphorylated LAT2 - interacts with PTPRJ - identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 & SOS1 - interacts (phosphorylated) with PTPN11 - interacts with HCK Structure: - belongs to the GAB family - contains 1 PH domain Alternative splicing: named isoforms=2

General

GRB2-associated binding protein

Properties

SIZE: entity length = 694 aa MW = 77 kD MOTIF: PH domain {5-116} Tyr phosphorylation site {Y183} Tyr phosphorylation site {Y259} Ser phosphorylation site {S266} Tyr phosphorylation site {Y373} Tyr phosphorylation site {Y406} proline-rich region SITE: 449-540 MOTIF: proline residue (SEVERAL) Thr phosphorylation site {T503} Tyr phosphorylation site {Y627} Tyr phosphorylation site {Y659}

Database Correlations

OMIM 604439 UniProt Q13480 Pfam PF00169 Entrez Gene 2549 Kegg hsa:2549

References

  1. UniProt :accession Q13480
  2. NIEHS-SNPs http://egp.gs.washington.edu/data/gab1/