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G protein-coupled receptor for asthma susceptibility (G-protein coupled receptor 154, vasopression-related receptor 1, neuropeptide S receptor, G-protein coupled receptor PGR14, NPSR1, GPR154, VPR1, GPRA, PGR14)

Function: 1) autocrine or paracrine signaling 2) receptor for neuropeptide S Structure: belongs to the G-protein coupled receptor 1 family Compartment: - isoforms 1,3,4: cell membrane - isoforms 2,5,6,7,9: cytoplasm Alternative splicing: named isoforms=9 Expression: ubiquitously expressed Pathology: 1) involved in pathogenesis of asthma and other IgE-mediated disease 2) NPSR1 is associated with susceptibility to asthma & elevated serum IgE levels - polymorphisms may influence the development of asthma - associated with allergic sensitization, rhinoconjunctivis, & asthma

General

G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 371 aa MW = 43 kD COMPARTMENT: cytoplasm MOTIF: exoplasmic domain {1-52} MOTIF: N-glycosylation site {N4} transmembrane domain {53-73} cytoplasmic loop {74-82} transmembrane domain {83-103} exoplasmic loop {104-123} MOTIF: cysteine residue {C121} MODIFICATION: cysteine residue {C197} transmembrane domain {124-144} cytoplasmic loop {145-164} transmembrane domain {165-185} exoplasmic loop {186-212} MOTIF: cysteine residue {C197} MODIFICATION: cysteine residue {C121} transmembrane domain {213-233} cytoplasmic loop {234-275} transmembrane domain {276-296} exoplasmic loop {297-312} transmembrane domain {313-333} cytoplasmic domain {334-371}

Database Correlations

OMIM correlations MORBIDMAP 608595 UniProt Q6W5P4 Pfam PF00001 Kegg hsa:3871

References

  1. OMIM :accession 608595
  2. Journal Watch 24(11):91, 2004
    1. Laitinen T, Polvi A, Rydman P, Vendelin J, Pulkkinen V, Salmikangas P, Makela S, Rehn M, Pirskanen A, Rautanen A, Zucchelli M, Gullsten H, Leino M, Alenius H, Petays T, Haahtela T, Laitinen A, Laprise C, Hudson TJ, Laitinen LA, Kere J. Characterization of a common susceptibility locus for asthma- related traits. Science. 2004 Apr 9;304(5668):300-4. PMID: 15073379
    2. Couzin J. Genetics. Two new asthma genes uncovered. Science. 2004 Apr 9;304(5668):185-7. No abstract available. PMID: 15073340
  3. UniProt :accession Q6W5P4
  4. SeattleSNPs http://pga.gs.washington.edu/data/gpr154/