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granulocyte colony-stimulating factor; colony-stimulating factor 3; G-CSF; pluripoietin (CSF3, C17orf33, GCSF)
Function:
- cytokine
- induces granulocytes
Structure:
- monomer
- belongs to the IL-6 superfamily
Compartment: secreted
Alternative splicing: named isoforms=2
Pharmacology:
- available as filgrastim under the names Neupogen or Granulokine (Amgen/Roche) & Granocyte (Rhone-Poulenc)
Related
granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 (CSF3R, GCSFR)
Specific
efbemalenograstim alfa-vuxw (Ryzneuta)
filgrastim [G-CSF] (Neupogen, Lenograstim, Granulokine)
omidubicel-onlv (Omisirge)
General
colony-stimulating factor (CSF)
glycoprotein
Properties
SIZE: entity length = 207 aa
MW = 22 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-29}
cysteine residue {C69}
MODIFICATION: cysteine residue {C75}
cysteine residue {C75}
MODIFICATION: cysteine residue {C69}
cysteine residue {C97}
MODIFICATION: cysteine residue {C107}
cysteine residue {C107}
MODIFICATION: cysteine residue {C97}
Thr glycosylation site {T166}
MISC-INFO: 1/2life 3-4 HOURS
Database Correlations
OMIM 138970
UniProt P09919
Pfam PF00489
Entrez Gene 1440
Kegg hsa:1440
References
- UniProt :accession P09919
- Neupogen/Granulokine;
Clinical information on Neupogen/Granulokine
http://www.neupogen.com/pi.html
- SeattleSNPs
http://pga.gs.washington.edu/data/csf3/
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908