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G-alpha

Function: - guanine nucleotide binding subunit of G-proteins - GTPase activty - GTPase activity could be unifying property of small GTP-binding proteins that convey their regulatory role to diverse protein interactions, each with a different application depending upon the duration of the required activation [2]

Interactions

molecular events

Specific

G12-alpha family Gi-alpha family Gq-alpha family (GNAQ) Gs-alpha family guanine nucleotide-binding protein G(t) subunit alpha-3 (gustducin alpha-3 chain, GNAT3)

General

guanosine triphosphatase (GTPase) phosphoprotein protein subunit

Properties

SIZE: MW = 41-52 kD COMPARTMENT: plasma membrane* CELL: most cell types* ORGANISM: eukaryote* MOTIF: binding site FOR-BINDING-OF: G-beta/gamma P-loop EFFECTOR-BOUND: guanosine triphosphate Mg+2-binding site

References

  1. Sagi-Eisenberg R GTP-binding proteins as possible targets for protein kinase C action TIBS 14:355 1989 PMID: 2512697
  2. Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: 8488557

Component-of

G-protein