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Fusobacterium
Pathology:
- abundance in GI tract increased in patients with colorectal cancer (odds ratio 4.11) [1]
- found in 50% of colorectal cancers [2]
- fusobacterial DNA found primarily within malignant cells [2]
- fusobacterial DNA also found colorectal cancer metastases [2]
Laboratory:
- Fusobacterium DNA
Management:
- sensitive to metronidazole [2]
Specific
Fusobacterium necrophorum
Fusobacterium nucleatum
General
Bacteroidaceae
Properties
KINGDOM: monera
DIVISION: SCHIZOMYCETES
References
- Ahn J, Sinha R, Pei Z et al
Human Gut Microbiome and Risk of Colorectal Cancer.
J Natl Cancer Inst (2013) Dec 6
PMID: 24316595
http://jnci.oxfordjournals.org/content/early/2013/11/27/jnci.djt300.abstract
- Mai V and Morris JG
Need for Prospective Cohort Studies to Establish Human Gut
Microbiome Contributions to Disease Risk.
Natl Cancer Inst (2013) Dec 6
PMID: 24316594
http://jnci.oxfordjournals.org/content/early/2013/11/27/jnci.djt349.full
- Bullman S, Pedamallu CS, Sicinska E et al.
Analysis of Fusobacterium persistence and antibiotic response
in colorectal cancer.
Science 2017 Dec 15; 358:1443
PMID: 29170280
http://science.sciencemag.org/content/358/6369/1443