serine/threonine protein kinase 36; fused Drosophila homolog of FU; fused homolog (STK36 KIAA1278)

Function: 1) postnatal development 2) homeostasis of cerebral spinal fluid 3) ciliary function 4) controls the activity of GLI1, GLI2, GLI3 5) opposes effect of SUFU 6) involved in hedgehog signaling 7) binds gli protein 8) interacts with SPAG16 & KIF27 (putative) Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, Ser/Thr protein kinase family - contains 1 protein kinase domain Alternative splicing: named isoforms=2 Expression: - expressed in adult testis - expressed at low levels in most fetal tissues, adult ovaries

Properties

SIZE: MW = 144 kD entity length = 1315 aa STATE: active state MOTIF: kinase domain SITE: 4-254 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 10-18 ATP-binding site NAME: ATP-binding site SITE: 33-33 aspartate residue {D125}

Database Correlations

OMIM 607652 UniProt Q9NRP7 PFAM correlations Entrez Gene 27148 ENZYME 2.7.11.1

References

UniProt :accession Q9NRP7