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Fusarium

Presumptively classified as Hypomycetes. Pathology: 1) Fusarium keratitis associated with contact lens solution, ReNu with MoistureLoc [2] 2) human pathogen in immunocompromised hosts 3) Fusarium skin lesions in immunosuppressed patients are almost always associated with disseminated myocosis [1] Clinical manifestations: 1) nodular or hemorrhagic skin lesions 2) pulmonary infiltrates Laboratory: 1) may appear identical to Aspergillus in tissue smears 2) may be cultured from blood or skin biopsy material 3) Fusarium IgE in serum Management: 1) amphotericin B 1.0-1.5 mg/kg/day IV 2) may be highly resistant to amphotericin B 3) liposomal amphotericin B + terbinafine has been used [3]

Specific

Fusarium culmorum Fusarium moniliforme Fusarium oxysporum Fusarium roseum Fusarium solani

General

Hypomycetes

Properties

KINGDOM: plant DIVISION: EUMYCOPHYTA

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 15, American College of Physicians, Philadelphia 1998, 2009
  2. Chang DC et al, Multistate outbreak of Fusarium keratitis associated with use of contact lens solution. JAMA 2006, 296:953 PMID: 16926355 http://jama.ama-assn.org/cgi/content/full/296/953
  3. Neuburger S et al Successful salvage treatment of disseminated cutaneous fusariosis with liposomal amphotericin B and terbinafine after allogeneic stem cell transplantation Transpl Infect Dis 2008 10(4):290-3 PMID: 18194367