far upstream element-binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75 (KHSRP, FUBP2)

Function: - binds to the dendritic targeting element - may play a role in mRNA trafficking (putative) - part of a ternary complex that binds to the downstream control sequence (DCS) of pre-mRNA - mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing - may interact with single- stranded DNA from the far-upstream element (FUSE) - may activate gene expression - also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs - phosphorylated upon DNA damage, probably by ATM or ATR - part of a ternary complex containing FUBP2, PTBP1, PTBP2 & HNRPH1 - interacts with PARN Structure: - belongs to the KHSRP family - contains 4 KH domains Compartment: - nucleus (putative), cytoplasm - a small proportion is also found in the cytoplasm of neuronal cell bodies & dendrites (putative) Alternative splicing: named isoforms=2 Expression: - detected in neural & non-neural cell lines

General

Far upstream element binding protein (FUSE binding protein) phosphoprotein

Properties

SIZE: entity length = 711 aa MW = 73 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T6} proline-rich region SITE: 7-67 MOTIF: proline residue (SEVERAL) glycine-rich region {68-496} MOTIF: Ser phosphorylation site {S99} Thr phosphorylation site {T100} Ser phosphorylation site {S132} KH domain SITE: 144-208 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S181} Ser phosphorylation site {S184} KH domain SITE: 233-299 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S274} KH domain SITE: 322-386 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 424-491 FOR-BINDING-OF: ribonucleic acid Ser phosphorylation site {S480} proline-rich region SITE: 498-612 MOTIF: proline residue (SEVERAL) 4 X 12 AA imperfect repeats {571-684} MOTIF: consensus repeat {571-582} consensus repeat {617-628} consensus repeat {643-654} Ser phosphorylation site {S670} consensus repeat {673-684}

Database Correlations

OMIM 603445 UniProt Q92945 PFAM correlations Entrez Gene 8570 Kegg hsa:8570

References

UniProt :accession Q92945