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follicle-stimulating hormone [FSH]-beta chain; follitropin beta chain (FSHB, Follistim)
Function:
- stimulates development of follicle & spermatogenesis in the reproductive organs
Structure:
- heterodimer of a common alpha chain (glycoprotein hormone alpha) & a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin & gonadotropin
- belongs to the glycoprotein hormones subunit beta family
Compartment: secreted
Pathology:
- defects in FSHB are a cause of isolated FSH deficiency
Pharmacology:
- available as Follistim
Laboratory:
- FSHB gene mutation
Related
follicle-stimulating hormone (FSH) in serum
follitropin.beta Ag in tissue
Specific
Fsh Beta Parenteral
urofollitropin (puregon, serono, organon, FSH-beta, Fertinex, Metrodin, Bravelle)
General
endocrine agent
glycoprotein hormone-beta chain
Properties
MOTIF: cysteine residue {C21}
MODIFICATION: cysteine residue {C69}
N-glycosylation site {N25}
cysteine residue {C35}
MODIFICATION: cysteine residue {C84}
cysteine residue {C38}
MODIFICATION: cysteine residue {C122}
N-glycosylation site {N42}
cysteine residue {C46}
MODIFICATION: cysteine residue {C100}
cysteine residue {C50}
MODIFICATION: cysteine residue {C102}
cysteine residue {C69}
MODIFICATION: cysteine residue {C21}
cysteine residue {C84}
MODIFICATION: cysteine residue {C35}
cysteine residue {C100}
MODIFICATION: cysteine residue {C46}
cysteine residue {C102}
MODIFICATION: cysteine residue {C50}
cysteine residue {C105}
MODIFICATION: cysteine residue {C112}
cysteine residue {C112}
MODIFICATION: cysteine residue {C105}
cysteine residue {C122}
MODIFICATION: cysteine residue {C38}
Database Correlations
OMIM correlations
UniProt P01225
Pfam PF00007
Kegg hsa:2488
References
- UniProt :accession P01225
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FSHB
- SHMPD; The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=FSHB
- Wikipedia; Follicle-stimulating hormone entry
http://en.wikipedia.org/wiki/Follicle_stimulating_hormone
Component-of
follicle-stimulating hormone; follitropin (FSH)