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protein furry homolog-like (ALL1-fused gene from chromosome 4p12, FRYL, AF4P12, KIAA0826)
Function:
- role in maintaining integrity of polarized cell extensions during morphogenesis
- regulates actin cytoskeleton
- role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites
- limits dendritic branching
- transcriptional activator (putative)
Structure: belongs to the furry protein family
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- higher expression in colon, placenta, brain & cells of lymphoid origin
Pathology:
- chromosomal translocation t(4;11)(p12;q23) involving FRYL with MLL is found in treatment-related acute lymphoblastic leukemia (ALL)
- forms a MLL-FRYL fusion protein
Related
protein furry homolog (FRY C13orf14)
General
phosphoprotein
Properties
SIZE: MW = 340 kD
entity length = 3013 aa
MOTIF: Ser phosphorylation site {S2272}
Breakpoint {2302-2302}
Database Correlations
UniProt O94915
References
- UniProt :accession O94915
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/Genes/AF4q12ID42970ch4p12.html