frizzled homolog protein

Function: - receptor for Wnt proteins - most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin & activation of Wnt target genes - a second signaling pathway involving PKC & Ca⁺² fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase - both pathways seem to involve interactions with G-proteins - may be involved in transduction & intercellular transmission of polarity information during tissue morphogenesis &/or in differentiated tissues Structure: - homologous to drosophila polarity gene frizzled

Specific

frizzled-10; Fz-10; hFz10; FzE7; CD350 (FZD10) frizzled-1; Fz-1; hFz1; FzE1 (FZD1) frizzled-2; Fz-2; hFz2; FzE2 (FZD2) Frizzled-3; Fz-3; hFz3 (FZD3) frizzled-4; Fz-4; hFz4; FzE4; CD344 (FZD4) frizzled-5; Fz-5; hFz5; FzE5 (FZD5) Frizzled-6; Fz-6; hFz6 (FZD6) frizzled-7; Fz-7; hFz7; FzE3 (FZD7) frizzled-8; Fz-8; hFz8 (FZD8) frizzled-9; Fz-9; hFz9; FzE6; CD349 (FZD9, FZD3)

Properties

COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {N-TERMINAL} exoplasmic loop LOOP#: 1 exoplasmic loop LOOP#: 2 exoplasmic loop LOOP#: 3 transmembrane domain {TM1} transmembrane domain {TM2} transmembrane domain {TM3} transmembrane domain {TM4} transmembrane domain {TM5} transmembrane domain {TM6} transmembrane domain {TM7} cytoplasmic loop LOOP#: 1 cytoplasmic loop LOOP#: 2 cytoplasmic loop LOOP#: 3 cytoplasmic domain {C-TERMINAL}

References

UniProt :accession Q9UP38