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free radical
A reactive molecule (radical) of short 1/2life implicated in:
1) aging [1]
2) degenerative diseases [2]
a) cancer
b) atherosclerosis
c) neurodegenerative diseases
3) oxidative stress Free implicates diffusion with reaction at a site distant to the site of generation (distinguished radicals within a solvent of compartmental cage).
General
radical
References
- Harman D, Aging: a theory based on free radical and radiation
chemistry, J Gerontol 11:298, 1956
- Harman D, Free radical theory of aging: Role of free radicals
in the origination and evolution of life, aging and disease
processes. In: Johnson JE et al (eds), Free Radicals, Aging
and Degenerative Diseases, New York, Liss, 1986