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free prostate Specific antigen/prostate specific antigen total in serum/plasma

Indications: - assessing risk of prostate cancer in patients with elevated serum PSA Clinical significance: - when serum PSA is > 4 ug/L (> 6 ug/L if > 65 years of age) & < 10 ug/L, serum free PSA/total PSA is useful for asessing risk of prostate cancer - if %free PSA is < 25%, then refer patient to urology for prostate biopsy, otherwise risk is low [2] - with a total PSA 4-10 ng/mL, 95% of men with prostate cancer have free PSA < 25%, 20% of men with BPH have free PSA < 25% [2]

General

analyte ratio

References

  1. Loinc
  2. Catalona WJ, Partin AW, Slawin KM et al Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA. 1998 May 20;279(19):1542-7. PMID: 9605898

Components

prostate specific antigen prostate specific antigen (PSA) in serum