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forkhead box protein N3; checkpoint suppressor 1 (FOXN3, C14orf116, CHES1)
Function:
- acts as a transcriptional repressor
- may be involved in DNA damage-inducible cell cycle arrests (checkpoints)
- interacts through its C-terminus with the C-terminus of SNW1/SKIP
Structure:
- contains 1 fork-head DNA-binding domain
Compartment:
- nucleus (probable)
Alternative splicing:
- named isoforms=2
General
DNA-binding protein
forkhead family transcription factor
phosphoprotein
Properties
SIZE: entity length = 490 aa
MW = 54 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S85}
fork head domain
NAME: fork head domain
SITE: 113-204
Database Correlations
OMIM 602628
UniProt O00409
Pfam PF00250
Entrez Gene 1112
Kegg hsa:1112
References
- UniProt :accession O00409
- Entrez Gene :accession 1112